Evening ISS: Transforming Gynecologic Cancer Treatment with Antibody-Drug Conjugates: Best Practices for Integrating Novel Therapies, Addressing Adverse Events, and Optimizing Multidisciplinary Collaboration
Supporting company: Med Learning Group
Friday, March 14 | 7:00-8:30 p.m. PT | Room 606-609
Faculty: Bradley J. Monk, MD, FACS, FACOG and Ursula A. Matulonis, MD
Antibody-drug conjugates (ADCs) are an important advancement in the treatment of cancer. We are pleased to present an informative satellite symposium designed to equip you with information and skills needed to optimally use ADCs for your patients with advanced gynecologic cancers. This program will use an interactive format that includes didactic presentations, case presentations, and discussion sessions, along with audience response technology. Renowned experts will review the latest evidence and clinical guidelines related to ADCs for women’s cancers and share their perspectives and guidance on incorporating these agents into practice, including individualized treatment planning and multidisciplinary toxicity monitoring and management.
- Describe the mechanisms of action of antibody-drug conjugates (ADCs) and the rationale for their use in gynecologic cancers
- Develop personalized strategies for incorporating ADCs into the treatment of patients with advanced gynecologic cancers
- Assess and manage adverse events associated with administration of ADCs in gynecologic cancers
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ISS I: Exploring the Horizons in Endometrial Cancer: Biomarkers, Guidelines, and Coordinated Care
Supporting company: Medscape LLC
Saturday, March 15 | 7:00-8:15 a.m. | Room: 6AB
Faculty: Mansoor Raza Mirza, MD; Ramez N. Eskander, MD; and Ritu Salani, MD, MBA
Recognizing that caring for patients with advanced endometrial cancer is a journey that must be appropriately mapped out, Medscape Oncology presents a 90-minute educational session to serve as a road map to the optimal path of care. A group of 3 world-renowned gynecologic oncologists will guide learners through the options and their choices at the different destinations.
- Increased knowledge regarding the rationale for immunotherapy in advanced endometrial cancer.
- Greater competence related to tailoring treatment based on standard-of-care practices for a patient with primary advanced endometrial cancer.
- Selecting the most optimal treatment option for a patient with recurrent advanced endometrial cancer.
- Managing adverse events associated therapies used to treat advanced endometrial cancer.
- Greater confidence in their ability to incorporate a multidisciplinary practice into treatment to optimize patient outcomes.
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ISS II: A New Era in Treating Advanced Ovarian Cancer: Practical Tips for Maximizing the Use of PARP Inhibitors, Immunotherapy, and ADCs
Supporting company: PeerView
Saturday, March 15 | 7:00-8:15 a.m. PT | Room 6E
Moderator: Kathleen N. Moore, MD, MS
Faculty: David M. O’Malley, MD and Bhavana Pothuri, MD, MS
- Gain insights into cutting-edge treatments for advanced ovarian cancer including PARP inhibitors, ADCs, and immunotherapy approaches
- Explore the most recent efficacy and safety data, along with practical guidance on integrating modern therapies into clinical practice
- Acquire actionable, team-based approaches to identify, mitigate, and manage treatment-related adverse events for improved patient care
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ISS III: Cases from the Community: Investigators Discuss the Optimal Clinical Care of Patients with HER2-Positive Gynecologic Cancers
Supporting company: Research to Practice
Saturday, March 15 | 12:30-2:00 p.m. PT | Room: 6AB
Moderator: David M O’Malley, MD
Faculty: Kathleen N. Moore, MD, MS and Alessandro D. Santin, MD
Module 1: Strategies to Identify Patients with HER2-Positive Gynecologic Cancers
- Incidence of HER2 expression documented among various gynecologic cancer subtypes
- Definition of HER2 positivity in the pivotal DESTINY-PanTumor02 study of trastuzumab deruxtecan (T-DXd)
- Appropriate integration of HER2 immunohistochemistry testing into routine gynecologic oncology practice
- Potential utility of other testing methods, such as next-generation sequencing and liquid biopsy, to identify patients with advanced gynecologic cancers who might benefit from HER2-targeted therapy
- Optimal source material for and timing of HER2 testing for advanced gynecologic cancers
Module 2: Available Data with and Practical Application of HER2-Targeted Therapy for Advanced Gynecologic Cancers
- Published research studies with HER2-targeted strategies, such as trastuzumab and pertuzumab/trastuzumab, for advanced endometrial cancer
- Limited clinical trial database surrounding the use of HER2-targeted therapy for other advanced gynecologic cancers
- Key efficacy outcomes achieved with T-DXd among patients with advanced ovarian, endometrial and cervical cancers in the DESTINY-PanTumor02 study
- Recent FDA approval of T-DXd for pretreated HER2-positive solid tumors; implications for the management of advanced gynecologic cancers
- Other novel agents and strategies under evaluation for patients with HER2-positive gynecologic cancers
Module 3: Identification and Management of Adverse Events (AEs) with T-DXd
- Spectrum and incidence of common (eg, gastrointestinal [GI] toxicities, myelosuppression) and more serious (eg, interstitial lung disease [ILD], cardiac toxicities) treatment-emergent AEs observed with T-DXd
- Recommendations for monitoring and immediate reporting of symptoms of ILD with T-DXd
- Strategies to manage T-DXd-associated ILD; indications for restarting T-DXd after resolution of symptoms
- Appropriate monitoring of complete blood counts and left ventricular ejection fraction during therapy with T-DXd
- Recommended algorithms for mitigating and managing cardiac toxicities, cytopenias, GI side effects and other complications of T-DXd
- Initial dosing of T-DXd and dose-modification strategies for patients with treatment-related toxicities
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ISS IV: Expert Panel Discussion: Maintenance Therapy in Advanced Ovarian Cancer – Results from Key Clinical Trials
Supporting company: AstraZeneca
Saturday, March 15 | 12:30-2:00 p.m. PT | Room: 6E
Faculty: Thomas Kirvack, MD; Cecelia Boardman, MD; and Thomas Herzog, MD
Join Drs. Krivak, Herzog, and Boardman for an interactive trivia-style presentation as they delve into key clinical trials and share their real-world insights on maintenance therapy in advanced ovarian cancer. Throughout the session, you’ll have the opportunity to participate in trivia questions designed to challenge and expand your knowledge of the subject.
ISS V: Building a Comprehensive Treatment Pathway in Ovarian Cancer
Supporting company: Medscape Education
Sunday, March 16 | 7:00-8:15 a.m. PT | Room 6AB
Faculty: Bradley J. Monk, MD, FACS, FACOG; Ursula A. Matulonis, MD; and Domenica Lorusso, MD, PhD
The pathways of care in advanced ovarian cancer have become increasingly complicated with the addition of numerous therapies and biomarkers that guide treatment decisions. Join us in Seattle as top ovarian cancer experts draw a roadmap to care based on real-world patient case scenarios, including the role of biomarkers in the treatment decision-making process, selection of first-line therapeutic regimens, management of treatment-related adverse events, and other practical considerations. Don’t miss your opportunity to interact with the experts!
ISS VI: Expanding the Arsenal: Innovative Strategies to Treat Platinum Resistant Ovarian Cancer
Supporting company: Corcept Therapeutics
Sunday, March 16 | 7:00-8:15 a.m. PT | Room 6E
Moderator: Thomas J. Herzog, MD
Faculty: Nicoletta Colombo, MD, PhD; Alexander B. Olawaiye, MD; and Lyndsay Willmott, MD
This symposium will focus on the latest advancements in the treatment of advanced, platinum-resistant high-grade epithelial ovarian cancer. Ovarian cancer remains a significant challenge in oncology, particularly for heavily pretreated patients. This symposium aims to provide critical insights into the efficacy of new treatment options beyond antibody drug conjugates (ADCs). This session will provide a comprehensive overview discussing the competitive landscape, treatment outcomes, and learning about new innovative therapies beyond ADCs.